Medicine | Oncology
CNS Tumors | Diffuse astrocytic and oligodendroglial tumors
Glioblastoma
Classification

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GLIOBLASTOMA WITH OLIGODENDROGLIOMA COMPONENT

Hinrichs BH, Newman S, Appin CL, Dunn W, Cooper L, Pauly R, Kowalski J, Rossi MR, Brat DJ.
Farewell to GBM-O: Genomic and transcriptomic profiling of glioblastoma with oligodendroglioma component reveals distinct molecular subgroups.
Acta Neuropathol Commun. 2016 Jan 13;4:4. doi: 10.1186/s40478-015-0270-7.
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GLIOBLASTOMA WITH PNET COMPONENT

Cernelc J.
Glioblastoma with a PNET component - Report of an emerging variant with therapeutic and prognostic implications.
Pathology. 2016 Feb;48 Suppl 1:S66. doi: 10.1016/j.pathol.2015.12.166.
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SUBTYPES

Evans C.
TCGA Scientists Discover Four Distinct Subtypes of Glioblastoma Distinguished by Gene Expression Patterns and Clinical Characteristics
The Cancer Genome Atlas, Posted: February 1, 2011
Comment on: Verhaak RG et al. (2010), Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.
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Itakura H, Achrol AS, Mitchell LA, Loya JJ, Liu T, Westbroek EM, Feroze AH, Rodriguez S, Echegaray S, Azad TD, Yeom KW, Napel S, Rubin DL, Chang SD, Harsh GR 4th, Gevaert O.
Magnetic resonance image features identify glioblastoma phenotypic subtypes with distinct molecular pathway activities.
Sci Transl Med. 2015 Sep 2;7(303):303ra138. doi: 10.1126/scitranslmed.aaa7582.
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Sidaway P.
CNS cancer: Glioblastoma subtypes revisited.
Nat Rev Clin Oncol. 2017 Aug 1. doi: 10.1038/nrclinonc.2017.122. [Epub ahead of print]
Comment on: Wang Q et al., Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
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Verhaak RG, Hoadley KA, Purdom E, Wang V, Qi Y, Wilkerson MD, Miller CR, Ding L, Golub T, Mesirov JP, Alexe G, Lawrence M, O'Kelly M, Tamayo P, Weir BA, Gabriel S, Winckler W, Gupta S, Jakkula L, Feiler HS, Hodgson JG, James CD, Sarkaria JN, Brennan C, Kahn A, Spellman PT, Wilson RK, Speed TP, Gray JW, Meyerson M, Getz G, Perou CM, Hayes DN; Cancer Genome Atlas Research Network.
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1.
Cancer Cell. 2010 Jan 19;17(1):98-110. doi: 10.1016/j.ccr.2009.12.020.
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Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Sauvé CG, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW.
Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment.
Cancer Cell. 2017 Jul 10;32(1):42-56.e6. doi: 10.1016/j.ccell.2017.06.003.
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