Medicine | Oncology
Prostate cancer
Prognosis
Prediction tool: Positive surgical margins


Home > Disciplines > Medicine > Oncology > Prostate cancer > Prognosis > Positive surgical margins


CONTENTS



OVERVIEW
Defining Clinically Meaningful Positive Surgical Margins
CLOSE SURGICAL MARGINS
MULTIFOCALITY AND MULTILOCATION
PSMs AND BCR
Focal positive surgical margin
PSMs AND PROGRESSION-FREE PROBABILITY
PSMs AND MORTALITY
PSMs PREDICT BCR BUT NOT LONG-TERM CLINICAL END POINTS
PSMs PREDICT BCR AND LONG-TERM CLINICAL END POINTS
PSMs AND EARLY POSTOPERATIVE PSA
PSMs AND SURGICAL TECHNIQUE
NEOADJUVANT ADT PRIOR TO RP
TOOLS TO PREDICT PSMs





OVERVIEW


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Chang S.
Commentary on significance of positive surgical margins.
J Urol. 2008 May;179(5 Suppl):S52. doi: 10.1016/j.juro.2008.03.003.
Comment on: Swindle P et al., Do margins matter? The prognostic significance of positive surgical margins in radical prostatectomy specimens. [J Urol. 2008 May]
Source | Full text | Similar articles



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De La Roca RL, Da Cunha IW, Bezerra SM, Da Fonseca FP.
Radical prostatectomy and positive surgical margins: relationship with prostate cancer outcome.
Int Braz J Urol. 2014 May-Jun;40(3):306-15. doi: 10.1590/S1677-5538.IBJU.2014.03.03.
Source | Full text | Similar articles



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Galetti TP, Cattaneo F, Coati I, Gardiman M.
[Positive surgical margins after radical prostatectomy].
Urologia. 2014 Jan-Mar;81(1):16-24. Italian
Source | Full text | Similar articles



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Kates M, Sopko NA, Han M, Partin AW, Epstein JI.
Importance of Reporting the Gleason Score at the Positive Surgical Margin Site: Analysis of 4,082 Consecutive Radical Prostatectomy Cases.
J Urol. 2016 Feb;195(2):337-42. doi: 10.1016/j.juro.2015.08.002. Epub 2015 Aug 8.
Source | Full text | Similar articles



.

Meeks JJ, Eastham JA.
Radical prostatectomy: positive surgical margins matter.
Urol Oncol. 2013 Oct;31(7):974-9. doi: 10.1016/j.urolonc.2011.12.011. Epub 2012 Jan 11.
Source | Full text | Similar articles



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Preston MA, Blute ML.
Positive Surgical Margins After Radical Prostatectomy: Does It Matter?
Eur Urol. 2014 Feb;65(2):314-5. doi: 10.1016/j.eururo.2013.08.037. Epub 2013 Aug 26.
Source | Full text | Similar articles



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Sooriakumaran P, Dev HS, Skarecky D, Ahlering T.
The importance of surgical margins in prostate cancer.
J Surg Oncol. 2016 Mar;113(3):310-5. doi: 10.1002/jso.24109. Epub 2016 Mar 23.
Source | Full text | Similar articles



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Swindle P, Eastham JA, Ohori M, Kattan MW, Wheeler T, Maru N, Slawin K, Scardino PT.
Do margins matter? The prognostic significance of positive surgical margins in radical prostatectomy specimens.
J Urol. 2008 May;179(5 Suppl):S47-51. doi: 10.1016/j.juro.2008.03.137.
Source | Full text | Similar articles



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Wadhwa H, Terris MK, Aronson WJ, Kane CJ, Amling CL, Cooperberg MR, Freedland SJ, Abern MR.
Long-term oncological outcomes of apical positive surgical margins at radical prostatectomy in the Shared Equal Access Regional Cancer Hospital cohort.
Prostate Cancer Prostatic Dis. 2016 Dec;19(4):423-428. doi: 10.1038/pcan.2016.45. Epub 2016 Oct 4.
Source | Full text | Similar articles



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Yossepowitch O, Briganti A, Eastham JA, Epstein J, Graefen M, Montironi R, Touijer K.
Positive surgical margins after radical prostatectomy: a systematic review and contemporary update.
Eur Urol. 2014 Feb;65(2):303-13. doi: 10.1016/j.eururo.2013.07.039. Epub 2013 Aug 3.
Source | Full text | Similar articles



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Zhang L, Wu B, Zha Z, Zhao H, Jiang Y, Yuan J.
Positive surgical margin is associated with biochemical recurrence risk following radical prostatectomy: a meta-analysis from high-quality retrospective cohort studies.
World J Surg Oncol. 2018 Jul 3;16(1):124. doi: 10.1186/s12957-018-1433-3.
Source | Full text | Similar articles



Defining Clinically Meaningful Positive Surgical Margins


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Martini A, Gandaglia G, Fossati N, Scuderi S, Bravi CA, Mazzone E, Stabile A, Scarcella S, Robesti D, Barletta F, Cucchiara V, Mirone V, Montorsi F, Briganti A.
Defining Clinically Meaningful Positive Surgical Margins in Patients Undergoing Radical Prostatectomy for Localised Prostate Cancer.
Eur Urol Oncol. 2019 Apr 4. pii: S2588-9311(19)30039-2. doi: 10.1016/j.euo.2019.03.006. [Epub ahead of print]
Source | Full text | Similar articles



RISK FACTORS OF POSITIVE SURGICAL MARGINS


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Porcaro AB, Sebben M, Corsi P, Tafuri A, Processali T, Pirozzi M, Amigoni N, Rizzetto R, Cacciamani G, Mariotto A, Diminutto A, Brunelli M, De Marco V, Siracusano S, Artibani W.
Risk factors of positive surgical margins after robot-assisted radical prostatectomy in high-volume center: results in 732 cases.
J Robot Surg. 2019 Apr 5. doi: 10.1007/s11701-019-00954-x. [Epub ahead of print]
Source | Full text | Similar articles



CLOSE SURGICAL MARGINS


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Herforth C, Stroup SP, Chen Z, Howard LE, Freedland SJ, Moreira DM, Terris MK, Aronson WJ, Cooperberg MR, Amling CL, Kane CJ.
Radical Prostatectomy and the Effect of Close Surgical Margins: Results from the SEARCH database.
BJU Int. 2018 Feb 23. doi: 10.1111/bju.14178. [Epub ahead of print]
Source | Full text | Similar articles



MULTIFOCALITY AND MULTILOCATION


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Wu S, Lin SX, Wirth GJ, Lu M, Lu J, Subtelny AO, Wang Z, Dahl DM, Olumi AF, Wu CL.
Impact of Multifocality and Multilocation of Positive Surgical Margin After Radical Prostatectomy on Predicting Oncological Outcome.
Clin Genitourin Cancer. 2018 Aug 30. pii: S1558-7673(18)30522-6. doi: 10.1016/j.clgc.2018.08.007. [Epub ahead of print]
Source | Full text | Similar articles



PSMs AND BCR


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Ahyai SA, Zacharias M, Isbarn H, Steuber T, Eichelberg C, Köllermann J, Fisch M, Karakiewicz PI, Huland H, Graefen M, Chun FK.
Prognostic significance of a positive surgical margin in pathologically organ-confined prostate cancer.
BJU Int. 2010 Aug;106(4):478-83. doi: 10.1111/j.1464-410X.2009.09162.x. Epub 2010 Jan 29.
Source | Full text | Similar articles



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Alkhateeb S, Alibhai S, Fleshner N, Finelli A, Jewett M, Zlotta A, Nesbitt M, Lockwood G, Trachtenberg J.
Impact of positive surgical margins after radical prostatectomy differs by disease risk group.
J Urol. 2010 Jan;183(1):145-50. doi: 10.1016/j.juro.2009.08.132. Epub 2009 Nov 13.
Source | Full text | Similar articles



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Ha YS, Kang DI, Kim JH, Joung JY, Yu J, Parihar JS, Salmasi AH, Horie S, Kim WJ, Yi Kim I.
Favorable risk factors in patients with positive surgical margin after robot-assisted radical prostatectomy.
Can J Urol. 2014 Jun;21(3):7290-7.
Source | Full text | Similar articles



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Ginzburg S, Nevers T, Staff I, Tortora J, Champagne A, Kesler SS, Laudone VP, Wagner JR.
Prostate cancer biochemical recurrence rates after robotic-assisted laparoscopic radical prostatectomy.
JSLS. 2012 Jul-Sep;16(3):443-50. doi: 10.4293/108680812X13462882736538.
Source | Full text | Similar articles



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Karakiewicz PI, Eastham JA, Graefen M, Cagiannos I, Stricker PD, Klein E, Cangiano T, Schröder FH, Scardino PT, Kattan MW.
Prognostic impact of positive surgical margins in surgically treated prostate cancer: multi-institutional assessment of 5831 patients.
Urology. 2005 Dec;66(6):1245-50. http://dx.doi.org/10.1016/j.urology.2005.06.108
Source | Full text | Similar articles



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Lu J, Wirth GJ, Wu S, Chen J, Dahl DM, Olumi AF, Young RH, McDougal WS, Wu CL.
A close surgical margin after radical prostatectomy is an independent predictor of recurrence.
J Urol. 2012 Jul;188(1):91-7. doi: 10.1016/j.juro.2012.02.2565. Epub 2012 May 12.
Source | Full text | Similar articles



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Meeks JJ, Eastham JA.
Radical prostatectomy: positive surgical margins matter.
Urol Oncol. 2013 Oct;31(7):974-9. doi: 10.1016/j.urolonc.2011.12.011. Epub 2012 Jan 11.
Source | Full text | Similar articles



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Ploussard G, Agamy MA, Alenda O, Allory Y, Mouracade P, Vordos D, Hoznek A, Abbou CC, de la Taille A, Salomon L.
Impact of positive surgical margins on prostate-specific antigen failure after radical prostatectomy in adjuvant treatment-naïve patients.
BJU Int. 2011 Jun;107(11):1748-54. doi: 10.1111/j.1464-410X.2010.09728.x. Epub 2010 Sep 30.
Source | Full text | Similar articles



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Song C, Kang T, Yoo S, Jeong IG, Ro JY, Hong JH, Kim CS, Ahn H.
Tumor volume, surgical margin, and the risk of biochemical recurrence in men with organ-confined prostate cancer.
Urol Oncol. 2013 Feb;31(2):168-74. doi: 10.1016/j.urolonc.2010.11.005. Epub 2011 Jun 29.
Source | Full text | Similar articles



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Warner JN, Nunez RN, Mmeje CO, Colby TV, Ferrigni RG, Humphreys MR, Andrews PE, Castle EP.
Impact of margin status at 37 months after robot assisted radical prostatectomy.
Can J Urol. 2011 Dec;18(6):6043-9.
Source | Abstract | Similar articles



GLEASON SCORE (≥4) HAS A BETTER PREDICTIVE VALUE THAN PATHOLOGICAL STAGE (pT2 OR pT3)...


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Roux V, Eyraud R, Brureau L, Gourtaud G, Senechal C, Fofana M, Blanchet P.
[Impact of Gleason score on biochemical recurrence free survival after radical prostatectomy with positive surgical margins].
Prog Urol. 2017 Jun - Jul;27(8-9):467-473. doi: 10.1016/j.purol.2017.05.003. Epub 2017 May 30. French.
Source | Full text | Similar articles



... OR MARGIN STATUS


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Schiavina R, Borghesi M, Fiorentino M, Brunocilla E, Manferrari F, Vagnoni V, Martorana G.
Identification of prostate cancer risk categories according to surgical margins status, pathological stage and Gleason score.
Int J Urol. 2013 Mar 21. doi: 10.1111/iju.12124. [Epub ahead of print]
Source | Full text | Similar articles



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Yamamoto S.
Editorial Comment from Dr Yamamoto to Identification of prostate cancer risk categories according to surgical margins status, pathological stage and Gleason score.
Int J Urol. 2013 Mar 21. doi: 10.1111/iju.12134. [Epub ahead of print]
Editorial relating to: Schiavina R et al, Identification of prostate cancer risk categories according to surgical margins status, pathological stage and Gleason score. Int J Urol. 2013 Mar 21. doi: 10.1111/iju.12124. [Epub ahead of print]
Source | Full text | Similar articles



GLEASON SCORE AT THE POSITIVE SURGICAL MARGIN


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Aktan M, Koç M.
The role of radiotherapy after radical prostatectomy.
Turk J Med Sci. 2015;45(2):460-1. Epub 2015 Apr 1.
Source | Full text | Similar articles



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Brimo F, Partin AW, Epstein JI.
Tumor grade at margins of resection in radical prostatectomy specimens is an independent predictor of prognosis.
Urology. 2010 Nov;76(5):1206-9. doi: 10.1016/j.urology.2010.03.090. Epub 2010 Aug 8.
Source | Full text | Similar articles



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Fine SW, Reuter VE.
Editorial comment. Tumor grade at margins of resection in radical prostatectomy specimens is an independent predictor of prognosis.
Urology. 2010 Nov;76(5):1209-10; author reply 1210-1. doi: 10.1016/j.urology.2010.04.038.
Source | Full text | Similar articles



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Kates M, Sopko NA, Han M, Partin AW, Epstein JI.
Importance of Reporting the Gleason Score at the Positive Surgical Margin Site: Analysis of 4,082 Consecutive Radical Prostatectomy Cases.
J Urol. 2016 Feb;195(2):337-42. doi: 10.1016/j.juro.2015.08.002. Epub 2015 Aug 8.
Source | Full text | Similar articles



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Özkanli SŞ, Zemher IE, Yildirim A, Gür HD, Balbay MD, Şenol S, Özkanli AO, Alkan E, Zenginkinet T, Aydin A, Çaşkurlu T.
Gleason score at the margin can predict biochemical recurrence after radical prostatectomy, in addition to preoperative PSA and surgical margin status.
Turk J Med Sci. 2014;44(3):397-403. Epub 2014 Mar 31.
Source | Full text | Similar articles



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Savdie R, Horvath LG, Benito RP, Rasiah KK, Haynes AM, Chatfield M, Stricker PD, Turner JJ, Delprado W, Henshall SM, Sutherland RL, Kench JG.
High Gleason grade carcinoma at a positive surgical margin predicts biochemical failure after radical prostatectomy and may guide adjuvant radiotherapy.
BJU Int. 2012 Jun;109(12):1794-800. doi: 10.1111/j.1464-410X.2011.10572.x. Epub 2011 Oct 12.
Source | Full text | Similar articles



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Susperregui J, Pierry C, Bonhomme B, Pasticier G, Bernhard JC, Capon G, Bensadoun H, Ballanger P, Ferrière JM, Robert G.
Influence du score de Gleason des marges chirurgicales de prostatectomie totale sur la récidive biologique.
Prog Urol. 2017 Oct;27(12):632-639. doi: 10.1016/j.purol.2017.07.239. Epub 2017 Aug 30. French.
Source | Full text | Similar articles



IMPACT OF ANATOMIC SITE


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Wadhwa H, Terris MK, Aronson WJ, Kane CJ, Amling CL, Cooperberg MR, Freedland SJ, Abern MR.
Long-term oncological outcomes of apical positive surgical margins at radical prostatectomy in the Shared Equal Access Regional Cancer Hospital cohort.
Prostate Cancer Prostatic Dis. 2016 Dec;19(4):423-428. doi: 10.1038/pcan.2016.45.
Source | Full text | Similar articles



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O'Neil LM, Walsh S, Cohen RJ, Lee S.
Prostate carcinoma with positive margins at radical prostatectomy: role of tumour zonal origin in biochemical recurrence.
BJU Int. 2015 Oct;116 Suppl 3:42-8. doi: 10.1111/bju.13173. Epub 2015 Jul 27.
Source | Full text | Similar articles



LENGTH OF POSITIVE SURGICAL MARGIN


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Cao D, Humphrey PA, Gao F, Tao Y, Kibel AS.
Ability of linear length of positive margin in radical prostatectomy specimens to predict biochemical recurrence.
Urology. 2011 Jun;77(6):1409-14. doi: 10.1016/j.urology.2010.10.059. Epub 2011 Jan 22.
Source | Full text | Similar articles



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Koskas Y, Lannes F, Branger N, Giusiano S, Guibert N, Pignot G, Walz J, Rossi D, Bastide C.
Extent of positive surgical margins following radical prostatectomy: impact on biochemical recurrence with long-term follow-up.
BMC Urol. 2019 May 15;19(1):37. doi: 10.1186/s12894-019-0470-8.
Source | Full text | Similar articles



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Servoll E, Vlatkovic L, Sæter T, Nesland JM, Axcrona U, Waaler G, Axcrona K.
The length of a positive surgical margin is of prognostic significance in patients with clinically localized prostate cancer treated with radical prostatectomy.
Urol Int. 2014;93(3):289-95. doi: 10.1159/000362342. Epub 2014 Aug 27.
Source | Full text | Similar articles



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Shikanov S, Marchetti P, Desai V, Razmaria A, Antic T, Al-Ahmadie H, Zagaja G, Eggener S, Brendler C, Shalhav A.
Short (≤ 1 mm) positive surgical margin and risk of biochemical recurrence after radical prostatectomy.
BJU Int. 2013 Apr;111(4):559-63. doi: 10.1111/j.1464-410X.2012.11340.x. Epub 2012 Jul 3.
Source | Full text | Similar articles



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Shikanov S, Song J, Royce C, Al-Ahmadie H, Zorn K, Steinberg G, Zagaja G, Shalhav A, Eggener S.
Length of positive surgical margin after radical prostatectomy as a predictor of biochemical recurrence.
J Urol. 2009 Jul;182(1):139-44. doi: 10.1016/j.juro.2009.02.139. Epub 2009 May 17.
Source | Full text | Similar articles



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Sooriakumaran P, Ploumidis A, Nyberg T, Olsson M, Akre O, Haendler L, Egevad L, Nilsson A, Carlsson S, Jonsson M, Adding C, Hosseini A, Steineck G, Wiklund P.
The impact of length and location of positive margins in predicting biochemical recurrence after robot-assisted radical prostatectomy with a minimum follow-up of 5 years.
BJU Int. 2015 Jan;115(1):106-13. doi: 10.1111/bju.12483. Epub 2013 Oct 4.
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Impact of single positive surgical margin


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Evren I, Hacıislamoğlu A, Ekşi M, Yavuzsan AH, Baytekin F, Çolakoğlu Y, Canoğlu D, Tugcu V.
The impact of single positive surgical margin features on biochemical recurrence after robotic radical prostatectomy.
Int Braz J Urol. 2018 Sep 10;44. doi: 10.1590/S1677-5538.IBJU.2017.0702. [Epub ahead of print]
Source | Full text | Similar articles



Focal positive surgical margin


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Gautier M, Aude M, Gerjon H, Jerome R, Jean S, Arnauld V, Mo S, Charles HR.
Risk of biochemical recurrence based on extent and location of positive surgical margins after robot-assisted laparoscopic radical prostatectomy.
BMC Cancer. 2018 Dec 27;18(1):1291. doi: 10.1186/s12885-018-5229-1.
Source | Full text | Similar articles



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Keller EX, Bachofner J, Britschgi AJ, Saba K, Mortezavi A, Kaufmann B, Fankhauser CD, Wild P, Sulser T, Hermanns T, Eberli D, Poyet C.
Prognostic value of unifocal and multifocal positive surgical margins in a large series of robot-assisted radical prostatectomy for prostate cancer.
World J Urol. 2018 Dec 5. doi: 10.1007/s00345-018-2578-y. [Epub ahead of print]
Source | Full text | Similar articles




Preisser F, Coxilha G, Heinze A, Oh S, Chun FK, Sauter G, Pompe RS, Huland H, Graefen M, Tilki D.
Impact of positive surgical margin length and Gleason grade at the margin on biochemical recurrence in patients with organ-confined prostate cancer.
Prostate. 2019 Sep 25. doi: 10.1002/pros.23908. [Epub ahead of print] -
Source . Similar articles



MARGIN-ASSOCIATED VARIABLES


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Calışkan S, Kaya C.
Re: Location, extent and number of positive surgical margins do not improve accuracy of predicting prostate cancer recurrence after radical prostatectomy. A. J. Stephenson, D. P. Wood, M. W. Kattan, E. A. Klein, P. T. Scardino, J. A. Eastham and B. S. Carver j urol 2009; 182: 1357-1363.
J Urol. 2011 Mar;185(3):1155. doi: 10.1016/j.juro.2010.10.074. Epub 2011 Jan 21.
Source | Full text | Similar articles



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Fontenot PA, Mansour AM.
Reporting positive surgical margins after radical prostatectomy: time for standardization.
BJU Int. 2013 Jun;111(8):E290-9. doi: 10.1111/j.1464-410X.2012.11640.x. Epub 2013 Mar 14.
Source | Full text | Similar articles



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Huang JG, Pedersen J, Hong MK, Harewood LM, Peters J, Costello AJ, Hovens CM, Corcoran NM.
Presence or absence of a positive pathological margin outperforms any other margin-associated variable in predicting clinically relevant biochemical recurrence in Gleason 7 prostate cancer.
BJU Int. 2013 May;111(6):921-7. doi: 10.1111/j.1464-410X.2012.11665.x. Epub 2013 Jan 25.
Source | Full text | Similar articles



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Nielsen ME.
How bad are positive margins after radical prostatectomy and how are they best managed?
J Urol. 2009 Oct;182(4):1257-8. doi: 10.1016/j.juro.2009.07.071. Epub 2009 Aug 14.
Source | Full text | Similar articles



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Stephenson AJ, Wood DP, Kattan MW, Klein EA, Scardino PT, Eastham JA, Carver BS.
Location, extent and number of positive surgical margins do not improve accuracy of predicting prostate cancer recurrence after radical prostatectomy.
J Urol. 2009 Oct;182(4):1357-63. doi: 10.1016/j.juro.2009.06.046. Epub 2009 Aug 14.
Source | Full text | Similar articles



PATIENTS WITH pT2+ HAVE SIMILAR BCR RISK TO PATIENTS WITH pT3a-


.

Schiavina R, Borghesi M, Fiorentino M, Brunocilla E, Manferrari F, Vagnoni V, Martorana G.
Identification of prostate cancer risk categories according to surgical margins status, pathological stage and Gleason score.
Int J Urol. 2013 Mar 21. doi: 10.1111/iju.12124. [Epub ahead of print]
Source | Full text | Similar articles



.*

Yamamoto S.
Editorial Comment from Dr Yamamoto to Identification of prostate cancer risk categories according to surgical margins status, pathological stage and Gleason score.
Int J Urol. 2013 Mar 21. doi: 10.1111/iju.12134. [Epub ahead of print]
Refers to: Schiavina R et al, Identification of prostate cancer risk categories according to surgical margins status, pathological stage and Gleason score. Int J Urol. 2013 Mar 21. doi: 10.1111/iju.12124. [Epub ahead of print]
Source | Full text | Similar articles



PATIENTS WITH pT2R1 HAVE SIMILAR BCR RISK TO PATIENTS WITH pT3aR0


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Abdollah F, Sun M, Suardi N, Gallina A, Capitanio U, Bianchi M, Tutolo M, Fossati N, Castiglione F, Freschi M, Karakiewicz P, Rigatti P, Montorsi F, Briganti A.
Presence of positive surgical margin in patients with organ-confined prostate cancer equals to extracapsular extension negative surgical margin. A plea for TNM staging system reclassification.
Urol Oncol. 2013 Nov;31(8):1497-503. doi: 10.1016/j.urolonc.2012.04.013. Epub 2012 May 15.
Source | Full text | Similar articles



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Eminaga O, Hinkelammert R, Titze U, Abbas M, Eltze E, Bettendorf O, Semjonow A.
The presence of positive surgical margins in patients with organ-confined prostate cancer results in biochemical recurrence at a similar rate to that in patients with extracapsular extension and PSA ≤ 10 ng/ml.
Urol Oncol. 2014 Jan;32(1):32.e17-25. doi: 10.1016/j.urolonc.2012.11.021. Epub 2013 Feb 19.
Source | Full text | Similar articles



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Leite KR, Hartmann C, Reis ST, Viana N, Dall'Oglio MF, Sant'Anna AC, Nesrallah A, Nesrallah L, Antunes AA, Camara-Lopes LH, Srougi M.
Biochemical recurrence rates are similar for pT2-positive surgical margins and pT3a.
Int Braz J Urol. 2014 Mar-Apr;40(2):146-53. doi: 10.1590/S1677-5538.IBJU.2014.02.03.
Source | Full text | Similar articles



PATIENTS WITH pT2R1 HAVE SIMILAR BCR RISK TO PATIENTS WITH NEGATIVE MARGINS


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Kim KB, Lee IJ, Kim TJ, Oh JJ, Lee S, Jeong S-J, Hong SK, Byun S-S
MP56-11 Prognostic value of focal positive surgical margins after radical prostatectomy.
J Urol. 2015 May 17.
Vol. 193, Issue 4, e685. Epub 2015 Apr.
Source | Meeting abstract



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Lee S, Kim KB, Jo JK, Ho JN, Oh JJ, Jeong SJ, Hong SK, Byun SS, Choe G, Lee SE.
Prognostic Value of Focal Positive Surgical Margins After Radical Prostatectomy.
Clin Genitourin Cancer. 2016 Aug;14(4):e313-9. doi: 10.1016/j.clgc.2015.12.013. Epub 2015 Dec 29.
Source | Full text | Similar articles



ROBOTIC-ASSISTED LAPAROSCOPIC RADICAL PROSTATECTOMY (RALP)


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Ginzburg S, Nevers T, Staff I, Tortora J, Champagne A, Kesler SS, Laudone VP, Wagner JR.
Prostate cancer biochemical recurrence rates after robotic-assisted laparoscopic radical prostatectomy.
JSLS. 2012 Jul-Sep;16(3):443-50. doi: 10.4293/108680812X13462882736538.
Source | Full text | Similar articles



PSMs AND PROGRESSION-FREE PROBABILITY


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Swindle P, Eastham JA, Ohori M, Kattan MW, Wheeler T, Maru N, Slawin K, Scardino PT.
Do margins matter? The prognostic significance of positive surgical margins in radical prostatectomy specimens.
J Urol. 2005 Sep;174(3):903-7.
Source | Full text | Similar articles



PSMs AND MORTALITY


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Boorjian SA, Karnes RJ, Crispen PL, Carlson RE, Rangel LJ, Bergstralh EJ, Blute ML.
The impact of positive surgical margins on mortality following radical prostatectomy during the prostate specific antigen era.
J Urol. 2010 Mar;183(3):1003-9. doi: 10.1016/j.juro.2009.11.039. Epub 2010 Jan 21.
Source | Full text | Similar articles



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Chalfin HJ, Dinizo M, Trock BJ, Feng Z, Partin AW, Walsh PC, Humphreys E, Han M.
Impact of surgical margin status on prostate-cancer-specific mortality.
BJU Int. 2012 Dec;110(11):1684-9. doi: 10.1111/j.1464-410X.2012.11371.x. Epub 2012 Jul 12.
Source | Full text | Similar articles



**

Kvåle R, Myklebust TÅ, Fosså SD, Aas K, Ekanger C, Helle SI, Honoré A, Møller B.
Impact of positive surgical margins on secondary treatment, palliative radiotherapy and prostate cancer-specific mortality. A population-based study of 13 198 patients.
Prostate. 2019 Dec;79(16):1852-1860. doi: 10.1002/pros.23911. Epub 2019 Sep 30.
Source . Similar articles



PSMs PREDICT BCR BUT NOT LONG-TERM CLINICAL END POINTS


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Boorjian SA, Tollefson MK, Rangel LJ, Bergstralh EJ, Karnes RJ.
Clinicopathological predictors of systemic progression and prostate cancer mortality in patients with a positive surgical margin at radical prostatectomy.
Prostate Cancer Prostatic Dis. 2012 Mar;15(1):56-62. doi: 10.1038/pcan.2011.36. Epub 2011 Aug 2.
Source | Full text | Similar articles



.

Chang S.
Commentary on significance of positive surgical margins.
J Urol. 2008 May;179(5 Suppl):S52. doi: 10.1016/j.juro.2008.03.003.
Comment on: Swindle P et al., Do margins matter? The prognostic significance of positive surgical margins in radical prostatectomy specimens. [J Urol. 2008 May]
Source | Full text | Similar articles



.*

Mauermann J, Fradet V, Fradet Y.
Reply from authors re: Martin Spahn, Steven Joniau. Positive surgical margin at radical prostatectomy: futile or surgeon-dependent predictor of prostate cancer death? Eur Urol 2013;64:26-8: adjuvant versus salvage radiotherapy in patients with positive surgical margins at radical prostatectomy: that is the question.
Eur Urol. 2013 Jul;64(1):28-9. doi: 10.1016/j.eururo.2012.10.047. Epub 2012 Nov 5.
Source | Full text | Similar articles



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Mauermann J, Fradet V, Lacombe L, Dujardin T, Tiguert R, Tetu B, Fradet Y.
The impact of solitary and multiple positive surgical margins on hard clinical end points in 1712 adjuvant treatment-naive pT2-4 N0 radical prostatectomy patients.
Eur Urol. 2013 Jul;64(1):19-25. doi: 10.1016/j.eururo.2012.08.002. Epub 2012 Aug 10.
Source | Full text | Similar articles



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Mithal P, Howard LE, Aronson WJ, Terris MK, Cooperberg MR, Kane CJ, Amling C, Freedland SJ.
Positive surgical margins in radical prostatectomy patients do not predict long-term oncological outcomes: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort.
BJU Int. 2016 Feb;117(2):244-8. doi: 10.1111/bju.13181. Epub 2015 Jun 23.
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Spahn M, Joniau S.
Positive surgical margin at radical prostatectomy: futile or surgeon-dependent predictor of prostate cancer death?
Eur Urol. 2013 Jul;64(1):26-8. doi: 10.1016/j.eururo.2012.08.063. Epub 2012 Sep 5.
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Yap SA.
Should we worry about positive surgical margins in prostate cancer?
BJU Int. 2016 Feb;117(2):207-8. doi: 10.1111/bju.13230. Epub 2016 Jan 10.
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Comment on: Mithal P et al, Positive surgical margins in radical prostatectomy patients do not predict long-term oncological outcomes: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort. BJU Int. 2016 Feb;117(2):244-8. doi: 10.1111/bju.13181. Epub 2015 Jun 23. Source / Full text



PSMs PREDICT BCR AND LONG-TERM CLINICAL END POINTS


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Pfitzenmaier J, Pahernik S, Tremmel T, Haferkamp A, Buse S, Hohenfellner M.
Positive surgical margins after radical prostatectomy: do they have an impact on biochemical or clinical progression?
BJU Int. 2008 Nov;102(10):1413-8. doi: 10.1111/j.1464-410X.2008.07791.x. Epub 2008 Jun 4.
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IMPACT OF ANATOMIC SITE


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Blute ML, Bostwick DG, Bergstralh EJ, Slezak JM, Martin SK, Amling CL, Zincke H.
Anatomic site-specific positive margins in organ-confined prostate cancer and its impact on outcome after radical prostatectomy.
Urology. 1997 Nov;50(5):733-9.
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PSMs AND EARLY POSTOPERATIVE PSA



Bessede T, Patard JJ.
Re: The Use of Early Postoperative Prostate-specific Antigen to Stratify Risk in Patients with Positive Surgical Margins After Radical Prostatectomy.
Eur Urol. 2016 Feb;69(2):372. doi: 10.1016/j.eururo.2015.10.061.*
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Comment on: Vesely S et al.,The use of early postoperative prostate-specific antigen to stratify risk in patients with positive surgical margins after radical prostatectomy. BMC Urol. 2014 Oct 2;14:79. doi: 10.1186/1471-2490-14-79. Source / Full text



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Brändle E, Hautmann O, Bachem M, Kleinschmidt K, Gottfried HW, Grünert A, Hautmann RE.
Serum half-life time determination of free and total prostate-specific antigen following radical prostatectomy--a critical assessment.
Urology. 1999 Apr;53(4):722-30.
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Hatano K, Okusa T, Ishizuya Y, Nakai Y, Nakayama M, Kakimoto KI, Nishimura K.
Postoperative early ultrasensitive prostate-specific antigen identifies patients at risk for biochemical recurrence in margin positive prostate cancers: a single-center study.
Jpn J Clin Oncol. 2016 Oct 12. [Epub ahead of print]
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Vesely S, Jarolim L, Duskova K, Schmidt M, Dusek P, Babjuk M.
The use of early postoperative prostate-specific antigen to stratify risk in patients with positive surgical margins after radical prostatectomy.
BMC Urol. 2014 Oct 2;14:79. doi: 10.1186/1471-2490-14-79.
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PSMs AND SURGICAL TECHNIQUE


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Alchin DR, Murphy D, Lawrentschuk N.
Predicting the risk of positive surgical margins following robotic-assisted radical prostatectomy (RARP): a review of the literature.
Minerva Urol Nefrol. 2016 Sep 28. DOI: 10.23736/S0393-2249.16.02681-3 [Epub ahead of print]
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Guru KA, Perlmutter AE, Sheldon MJ, Butt ZM, Zhang S, Tan W, Wilding G, Kim HL, Mohler JL.
Apical margins after robot-assisted radical prostatectomy: does technique matter?
J Endourol. 2009 Jan 29;23(1):123-7. doi: 10.1089/end.2008.0398.
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Røder MA, Thomsen FB, Christensen IJ, Toft BG, Brasso K, Vainer B, Iversen P.
Risk factors associated with positive surgical margins following radical prostatectomy for clinically localized prostate cancer: can nerve-sparing surgery increase the risk?
Scand J Urol. 2014 Feb;48(1):15-20. doi: 10.3109/00365599.2012.749425. Epub 2012 Nov 27.
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SURGEON’S EXPERIENCE


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Bravi CA, Tin A, Vertosick E, Mazzone E, Martini A, Dell'Oglio P, Stabile A, Gandaglia G, Fossati N, Suardi N, Gallina A, Briganti A, Montorsi F, Vickers A.
The Impact Of Experience On The Risk Of Surgical Margins And Biochemical Recurrence After Robot-Assisted Radical Prostatectomy: A Learning-Curve Study.
J Urol. 2019 Feb 7. doi: 10.1097/JU.0000000000000147. [Epub ahead of print]
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NEOADJUVANT ADT PRIOR TO RP


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McClintock TR, von Landenberg N, Cole AP, Lipsitz SR, Gild P, Sun M, Fletcher SA, Roghmann F, Menon M, Nguyen PL, Noldus J, Choueiri TK, Kibel AS, Trinh QD.
Neoadjuvant Androgen Deprivation Therapy Prior to Radical Prostatectomy: Recent Trends in Utilization and Association with Postoperative Surgical Margin Status.
Ann Surg Oncol. 2018 Nov 14. doi: 10.1245/s10434-018-7035-z. [Epub ahead of print]
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TOOLS TO PREDICT PSMs




P.R.O.S.T.A.T.E. SCORE


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Xu B, Luo C, Zhang Q, Jin J.
Preoperative characteristics of the P.R.O.S.T.A.T.E. scores: a novel predictive tool for the risk of positive surgical margin after radical prostatectomy.
J Cancer Res Clin Oncol. 2017 Apr;143(4):687-692. doi: 10.1007/s00432-016-2313-2. Epub 2016 Dec 5.
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PSA DENSITY AND SURGEON VOLUME


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Hashimoto T, Yoshioka K, Gondo T, Takeuchi H, Nakagami Y, Nakashima J, Tachibana M.
Predictors for positive surgical margins after robot-assisted radical prostatectomy: A single surgeon's series in Japan.
Int J Urol. 2013 Feb 19. doi: 10.1111/iju.12081. [Epub ahead of print]
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