Medicine | Oncology
Prostate cancer
Treatment | BCR after primary treatment
Assessment of metastases


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GENERAL CONSIDERATIONS

DETECTION OF LOCAL RECURRENCES AND DISTANT METASTASES
■ USUAL IMAGING TECHNIQUES: BONE SCAN AND ABDOMINOPELVIC COMPUTED TOMOGRAPHY
■ CHOLINE AND ACETATE POSITRON EMISSION TOMOGRAPHY (PET)/COMPUTED TOMOGRAPHY (CT)
■ ■ Sensitivity and specificity
■ ■ Bone metastases
■ ■ Pelvic lymph node metastases
■ ■ Medical management of patients with bcf after primary treatment
■ ■ Strong dependency of sensitivity on the psa level and kinetics
■ ■ Optimal psa cutoff level after RP
■ ■ Optimal psa cutoff level after RT
■ OTHER RADIONUCLIDE TECHNIQUES
■ WHOLE-BODY AND AXIAL MAGNETIC RESONANCE IMAGING (MRI)

ASSESSMENT OF LOCAL RECURRENCES
■ LOCAL RECURRENCE AFTER RADICAL PROSTATECTOMY
■ ■ Transrectal ultrasound (trus) guided anastomotic biopsy
■ ■ Dynamic contrast-enhanced MRI
■ ■ Multiparametric mri (mpMRI)
■ ■ Choline or acetate PET/CT
■ LOCAL RECURRENCE AFTER RADIATION THERAPY
■ ■ Multiparametric mri (mpMRI)
■ ■ Choline or acetate PET/CT

GUIDELINES FOR IMAGING AFTER TREATMENT WITH CURATIVE INTENT





GENERAL CONSIDERATIONS


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Mottet N, Bellmunt J, Briers E, van den Bergh RCN, Bolla M, van Casteren NJ,  Cornford P, Culine S, Joniau S, Lam T, Mason MD, Matveev V, van der Poel H, van der Kwast TH, Rouvière O, Wiegel T.
Guidelines on Prostate Cancer.
European Association of Urology. Update March 2015. Page 81-83.
Source | Abstract | Full text



DETECTION OF LOCAL RECURRENCES AND DISTANT METASTASES




Usual imaging techniques: Bone scan and abdominopelvic computed tomography


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Beresford MJ, Gillatt D, Benson RJ, Ajithkumar T.
A systematic review of the role of imaging before salvage radiotherapy for post-prostatectomy biochemical recurrence.
Clin Oncol (R Coll Radiol). 2010 Feb;22(1):46-55. doi: 10.1016/j.clon.2009.10.015. Epub 2009 Nov 30.-719
Source | Full text | Similar articles



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Gomez P, Manoharan M, Kim SS, Soloway MS.
Radionuclide bone scintigraphy in patients with biochemical recurrence after radical prostatectomy: when is it indicated?
BJU Int. 2004 Aug 3;94(3):299-302.-720
Source | Full text | Similar articles



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Kane CJ, Amling CL, Johnstone PA, Pak N, Lance RS, Thrasher JB, Foley JP, Riffenburgh RH, Moul JW.
Limited value of bone scintigraphy and computed tomography in assessing biochemical failure after radical prostatectomy.
Urology. 2003 Mar;61(3):607-11.-721
Source | Full text | Similar articles



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Prando A.
Editorial comment. Rouvière O, Vitry T, Lyonnet D, Imaging of prostate cancer local recurrences: why and how?
Int Braz J Urol. vol.36 no.3 Rio de Janeiro May/June 2010
Source | Abstract | Full text



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Rouvière O, Vitry T, Lyonnet D.
Imaging of prostate cancer local recurrences: why and how?
Eur Radiol. 2010 May;20(5):1254-66. doi: 10.1007/s00330-009-1647-4. Epub 2009 Nov 17.-718
Source | Full text | Similar articles | Meeting slides



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Thurairaja R.
Radionuclide bone scintigraphy in patients with biochemical recurrence after radical prostatectomy: when is it indicated?
BJU Int. Vol. 95, Issue 1, pages 189–190, Jan 2005.  Source first published online: 20 Dec 2004.
Source | Full text | Similar articles



Choline and Acetate positron emission tomography (PET)/computed tomography (CT)


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Brogsitter C, Zöphel K, Kotzerke J.
18F-Choline, 11C-choline and 11C-acetate PET/CT: comparative analysis for imaging prostate cancer patients.
Eur J Nucl Med Mol Imaging. 2013 Jul;40 Suppl 1:S18-27. doi: 10.1007/s00259-013-2358-2. Epub 2013 Apr 12.-240
Source | Full text | Similar articles



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Welle CL, Cullen EL, Peller PJ, Lowe VJ, Murphy RC, Johnson GB, Binkovitz LA.
(11)C-Choline PET/CT in Recurrent Prostate Cancer and Nonprostatic Neoplastic Processes.
Radiographics. 2016 Jan-Feb;36(1):279-92. doi: 10.1148/rg.2016150135.
Source | Full text | Similar articles



Sensitivity and specificity


.

Brogsitter C, Zöphel K, Kotzerke J.
18F-Choline, 11C-choline and 11C-acetate PET/CT: comparative analysis for imaging prostate cancer patients.
Eur J Nucl Med Mol Imaging. 2013 Jul;40 Suppl 1:S18-27. doi: 10.1007/s00259-013-2358-2. Epub 2013 Apr 12.-240
Source | Full text | Similar articles



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Treglia G, Ceriani L, Sadeghi R, Giovacchini G, Giovanella L.
Relationship between prostate-specific antigen kinetics and detection rate of radiolabelled choline PET/CT in restaging prostate cancer patients: a meta-analysis.
Clin Chem Lab Med. 2014 May;52(5):725-33. doi: 10.1515/cclm-2013-0675.-722
Source | Full text | Similar articles

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724



Bone metastases

725


726


248


727



Pelvic lymph node metastases

728


729


730


731


242



Medical management of patients with BCF after primary treatment

732


733


734


735



Strong dependency of sensitivity on the PSA level and kinetics

240


722


724


736



Optimal PSA cutoff level after RP

724


736



Optimal PSA cutoff level after RT

724


737


738


ASSESSMENT OF LOCAL RECURRENCES




Local recurrence after radical prostatectomy



Transrectal ultrasound (TRUS) guided anastomotic biopsy

718



Dynamic contrast-enhanced MRI

741


742


743



Multiparametric MRI (mpMRI)

744


745



Choline or Acetate PET/CT

723


746


Local recurrence after radiation therapy



Multiparametric MRI (mpMRI)

718


747


748


749



Choline or Acetate PET/CT

732


733


738


750




GUIDELINES FOR IMAGING


.

Mottet N, Bellmunt J, Briers E, van den Bergh RCN, Bolla M, van Casteren NJ,  Cornford P, Culine S, Joniau S, Lam T, Mason MD, Matveev V, van der Poel H, van der Kwast TH, Rouvière O, Wiegel T.
Guidelines on Prostate Cancer.
European Association of Urology. Update March 2015. Page 81-83.
Source | Full text