CONTENTS
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TREATMENT OPTIONS
■
OVERVIEW
■ ELECTRIC
FIELDS
■ NIMOTUZUMAB
■ PERSONALIZED
TREATMENT
■ PROTEIN
KINASE INHIBITORS
■
RADIATION
THERAPY
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Laboratory
investigations
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El-Khouly FE, van Vuurden DG, Stroink T, Hulleman E, Kaspers GJL,
Hendrikse NH, Veldhuijzen van Zanten SEM.
Effective Drug
Delivery in Diffuse Intrinsic Pontine Glioma: A Theoretical Model
to Identify Potential Candidates.
Front Oncol. 2017 Oct
30;7:254. doi: 10.3389/fonc.2017.00254. eCollection 2017.
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Hashizume
R.
Epigenetic
Targeted Therapy for Diffuse Intrinsic Pontine Glioma.
Neurol
Med Chir (Tokyo). 2017 Jun 7. doi: 10.2176/nmc.ra.2017-0018. [Epub
ahead of print]
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PALBOCICLIB
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Sun Y, Sun Y, Yan K, Li Z, Xu C, Geng Y, Pan C, Chen X, Zhang L,
Xi Q.
Potent anti-tumor efficacy of palbociclib in
treatment-naïve H3.3K27M-mutant diffuse intrinsic pontine
glioma.
EBioMedicine. 2019 May;43:171-179. doi:
10.1016/j.ebiom.2019.04.043. Epub 2019 May 3.
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Clinical
investigations
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MULTIMODAL
TREATMENT
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Massimino M, Biassoni V, Miceli R, Schiavello E, Warmuth-Metz M,
Modena P, Casanova M, Pecori E, Giangaspero F, Antonelli M,
Buttarelli FR, Potepan P, Pollo B, Nunziata R, Spreafico F, Podda
M, Anichini A, Clerici CA, Sardi I, De Cecco L, Bode U, Bach F,
Gandola L.
Correction to: Results of nimotuzumab and
vinorelbine, radiation and re-irradiation for diffuse pontine
glioma in childhood.
J Neurooncol. 2018 May 16. doi:
10.1007/s11060-018-2893-6. [Epub ahead of print]
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Massimino M, Biassoni V, Miceli R, Schiavello E, Warmuth-Metz M,
Modena P, Casanova M, Pecori E, Giangaspero F, Antonelli M,
Buttarelli FR, Potepan P, Pollo B, Nunziata R, Spreafico F, Podda
M, Anichini A, Clerici CA, Sardi I, De Cecco L, Bode U, Bach F,
Gandola L.
Results of nimotuzumab and vinorelbine,
radiation and re-irradiation for diffuse pontine glioma in
childhood.
J Neurooncol. 2014 Jun;118(2):305-312. doi:
10.1007/s11060-014-1428-z. Epub 2014 Apr 3. Erratum in: J
Neurooncol. 2018 May 16;
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BEVACIZUMAB
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Moriya S, Ohba S, Adachi K, Nishiyama Y, Hayashi T, Nagahisa S,
Kaito T, Nakae S, Hirose Y.
A retrospective study of
bevacizumab for treatment of brainstem glioma with malignant
features.
J Clin Neurosci. 2017 Oct 16. pii:
S0967-5868(17)31445-5. doi: 10.1016/j.jocn.2017.10.002. [Epub
ahead of print]
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CHEMOTHERAPY
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Kilburn LB, Kocak M, Baxter P, Poussaint TY, Paulino AC, McIntyre
C, Lemenuel-Diot A, Lopez-Diaz C, Kun L, Chintagumpala M, Su JM,
Broniscer A, Baker JN, Hwang EI, Fouladi M, Boyett JM, Blaney SM.
A pediatric brain tumor consortium phase II trial of
capecitabine rapidly disintegrating tablets with concomitant
radiation therapy in children with newly diagnosed diffuse
intrinsic pontine gliomas.
Pediatr Blood Cancer. 2017
Nov 1. doi: 10.1002/pbc.26832. [Epub ahead of print]
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Sewing
AC, Lagerweij T, van Vuurden DG, Meel MH, Veringa SJ, Carcaboso
AM, Gaillard PJ, Peter Vandertop W, Wesseling P, Noske D, Kaspers
GJ, Hulleman E.
Preclinical
evaluation of convection-enhanced delivery of liposomal
doxorubicin to treat pediatric diffuse intrinsic pontine glioma
and thalamic high-grade glioma.
J
Neurosurg Pediatr. 2017 Feb 17:1-13. doi:
10.3171/2016.9.PEDS16152. [Epub ahead of print]
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van Zanten SEMV, El-Khouly FE, Jansen MHA, Bakker DP, Aliaga ES,
Haasbeek CJA, Wolf NI, Zwaan CM, Vandertop WP, van Vuurden DG,
Kaspers GJL.
Correction to: A phase I/II study of
gemcitabine during radiotherapy in children with newly diagnosed
diffuse intrinsic pontine glioma.
J Neurooncol. 2017
Oct 23. doi: 10.1007/s11060-017-2636-0. [Epub ahead of print]
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Veldhuijzen
van Zanten SEM, El-Khouly FE, Jansen MHA, Bakker DP, Sanchez
Aliaga E, Haasbeek CJA, Wolf NI, Zwaan CM, Vandertop WP, van
Vuurden DG, Kaspers GJL.
A
phase I/II study of gemcitabine during radiotherapy in children
with newly diagnosed diffuse intrinsic pontine glioma.
J
Neurooncol. 2017 Jul 26. doi: 10.1007/s11060-017-2575-9. [Epub
ahead of print]
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CONVECTION-ENHANCED
DELIVERY
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Himes BT, Zhang L, Daniels DJ.
Treatment Strategies in
Diffuse Midline Gliomas With the H3K27M Mutation: The Role of
Convection-Enhanced Delivery in Overcoming Anatomic Challenges.
Front Oncol. 2019 Feb 8;9:31. doi:
10.3389/fonc.2019.00031. eCollection 2019.
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Souweidane MM, Kramer K, Pandit-Taskar N, Zhou Z, Haque S,
Zanzonico P, Carrasquillo JA, Lyashchenko SK, Thakur SB, Donzelli
M, Turner RS, Lewis JS, Cheung NV, Larson SM, Dunkel IJ.
Convection-enhanced delivery for diffuse intrinsic
pontine glioma: a single-centre, dose-escalation, phase 1 trial.
Lancet Oncol. 2018 Jun 15. pii: S1470-2045(18)30322-X.
doi: 10.1016/S1470-2045(18)30322-X. [Epub ahead of print]
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van Vuurden DG.
Convection-enhanced delivery:
chemosurgery in diffuse intrinsic pontine glioma.
Lancet
Oncol. 2018 Jun 15. pii: S1470-2045(18)30408-X. doi:
10.1016/S1470-2045(18)30408-X. [Epub ahead of print]
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IMMUNOTHERAPY
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Tejada S, Alonso M, Patiño A, Fueyo J, Gomez-Manzano C,
Diez-Valle R.
Phase I Trial of DNX-2401 for Diffuse
Intrinsic Pontine Glioma Newly Diagnosed in Pediatric Patients.
Neurosurgery. 2017 Oct 27. doi: 10.1093/neuros/nyx507. [Epub
ahead of print]
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INHIBITORS
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PDGFRA
INHIBITOR+ C-MET INHIBITOR
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Broniscer A, Jia S, Mandrell B, Hamideh D, Huang J, Onar-Thomas A,
Gajjar A, Raimondi SC, Tatevossian RG, Stewart CF.
Phase
1 trial, pharmacokinetics, and pharmacodynamics of dasatinib
combined with crizotinib in children with recurrent or progressive
high-grade and diffuse intrinsic pontine glioma.
Pediatr
Blood Cancer. 2018 Mar 7. doi: 10.1002/pbc.27035. [Epub ahead of
print]
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RADIOTHERAPY
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Freese
C, Takiar V, Fouladi M, DeWire M, Breneman J, Pater L.
Radiation
and subsequent reirradiation outcomes in the treatment of diffuse
intrinsic pontine glioma and a systematic review of the
reirradiation literature.
Pract
Radiat Oncol. 2017 Mar - Apr;7(2):86-92. doi:
10.1016/j.prro.2016.11.005. Epub 2016 Nov 23.
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Janssens
GO, Gandola L, Bolle S, Mandeville H, Ramos-Albiac M, van Beek K,
Benghiat H, Hoeben B, Morales La Madrid A, Kortmann RD, Hargrave
D, Menten J, Pecori E, Biassoni V, von Bueren AO, van Vuurden DG,
Massimino M, Sturm D, Peters M, Kramm CM.
Survival
benefit for patients with diffuse intrinsic pontine glioma (DIPG)
undergoing re-irradiation at first progression: A matched-cohort
analysis on behalf of the SIOP-E-HGG/DIPG working group.
Eur
J Cancer. 2017 Mar;73:38-47. doi: 10.1016/j.ejca.2016.12.007. Epub
2017 Feb 3.
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Lassaletta A, Strother D, Laperriere N, Hukin J, Vanan MI, Goddard
K, Lafay-Cousin L, Johnston DL, Zelcer S, Zapotocky M, Rajagopal
R, Ramaswamy V, Hawkins C, Tabori U, Huang A, Bartels U, Bouffet
E.
Reirradiation in patients with diffuse intrinsic
pontine gliomas: The Canadian experience.
Pediatr Blood
Cancer. 2018 Jan 25. doi: 10.1002/pbc.26988. [Epub ahead of print]
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Morales
La Madrid A, Santa-María V, Cruz Martinez O, Mora J, Puerta
Roldan P, Guillen Quesada A, Suñol Capella M, de Torres
Gomez-Pallete C, Lassaletta A, Laperriere N, Villà S,
Bouffet E.
Second
re-irradiation for DIPG progression, re-considering "old
strategies" with new approaches.
Childs
Nerv Syst. 2017 Mar 1. doi: 10.1007/s00381-017-3352-y. [Epub ahead
of print]
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Tinkle
CL, Orr BA, Lucas JT Jr, Klimo P, Patay Z, Baker SJ, Broniscer A,
Qaddoumi I.
Rapid
and fulminant leptomeningeal spread following radiotherapy in
diffuse intrinsic pontine glioma.
Pediatr
Blood Cancer. 2017 Jan 13. doi: 10.1002/pbc.26416. [Epub ahead of
print]
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Wang
ZJ, Ge Y, Altinok D, Poulik J, Sood S, Taub JW, Edwards H, Kieran
MW, Steven M.
Concomitant
Use of Panobinostat and Reirradiation in Progressive DIPG: Report
of 2 Cases.
J
Pediatr Hematol Oncol. 2017 Feb 23. doi:
10.1097/MPH.0000000000000806. [Epub ahead of print]
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REIRRADIATION
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Amsbaugh MJ, Mahajan A, Thall PF, McAleer MF, Paulino AC,
Grosshans D, Khatua S, Ketonen L, Fontanilla H, McGovern SL.
A
Phase 1/2 Trial of Reirradiation for Diffuse Intrinsic Pontine
Glioma.
Int J Radiat Oncol Biol Phys. 2019 Jan 2. pii:
S0360-3016(18)34225-1. doi: 10.1016/j.ijrobp.2018.12.043. [Epub
ahead of print]
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RADIOCHEMOTHERAPY
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Seidel C, von Bueren AO, Bojko S, Hoffmann M, Pietsch T, Gielen
GH, Warmuth-Metz M, Bison B, Kortmann RD, Kramm CM.
Concurrent
radiotherapy with temozolomide vs. concurrent radiotherapy with
a cisplatinum-based polychemotherapy regimen : Acute toxicity
in pediatric high-grade glioma patients.
Strahlenther
Onkol. 2017 Oct 11. doi: 10.1007/s00066-017-1218-6. [Epub ahead of
print]
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SURGERY
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Fernandes Cabral DT, Zenonos GA, Nuñez M, Celtikci P,
Snyderman C, Wang E, Gardner PA, Fernandez-Miranda JC.
Endoscopic
Endonasal Transclival Approach for Resection of a Pontine Glioma:
Surgical Planning, Surgical Anatomy, and Technique.
Oper
Neurosurg (Hagerstown). 2018 Mar 12. doi: 10.1093/ons/opy005.
[Epub ahead of print]
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Guida L, Roux FE, Massimino M, Marras CE, Sganzerla E, Giussani C.
Safety and efficacy of Endoscopic Third Ventriculostomy
in Diffuse Intrinsic Pontine Glioma related hydrocephalus: a
Systematic Review.
World Neurosurg. 2018 Dec 30. pii:
S1878-8750(18)32919-X. doi: 10.1016/j.wneu.2018.12.096. [Epub
ahead of print]
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