Medicine | Oncology
CNS Tumors | Gliomas

Diffuse midline
gliomas | Treatment
Protein kinase inhibitors


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Contents



Overview
Laboratory Investigations
Clinical investigations
Newly diagnosed tumors
Recurrent tumors
Miscellanea



Overview






Laboratory investigations




PPM1D INHIBITORS


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Akamandisa MP, Nie K, Nahta R, Hambardzumyan D, Castellino RC.
Inhibition of mutant PPM1D enhances DNA damage response and growth suppressive effects of ionizing radiation in diffuse intrinsic pontine glioma.
Neuro Oncol. 2019 Mar 10. pii: noz053. doi: 10.1093/neuonc/noz053. [Epub ahead of print]
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Clinical investigations




Newly diagnosed tumors




Recurrent tumors




REGORAFENIB


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Kebir S, Rauschenbach L, Radbruch A, Lazaridis L, Schmidt T, Stoppek AK, Pierscianek D, Stuschke M, Forsting M, Sure U, Keyvani K, Kleinschnitz C, Scheffler B, Glas M.
Regorafenib in patients with recurrent high-grade astrocytoma.
J Cancer Res Clin Oncol. 2019 Apr;145(4):1037-1042. doi: 10.1007/s00432-019-02868-5. Epub 2019 Feb 28.
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Miscellanea