Medicine | Oncology
Prostate cancer
Treatment
Biochemical recurrence after primary treatment


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CONTENTS



DEFINITION OF BIOCHEMICAL RECURRENCE (BCR)

NATURAL HISTORY OF BIOCHEMICAL RECURRENCE

ASSESSMENT OF METASTASES

TREATMENT OF BIOCHEMICAL RECURRENCE AFTER RADICAL PROSTATECTOMY
OVERVIEW
SALVAGE RADIOTHERAPY (SRT)
ANDROGEN DEPRIVATION THERAPY (ADT)
TREATMENT OPTIONS OTHER THAN RADIATION AND ANDROGEN DEPRIVATION
OBSERVATION

TREATMENT OF BIOCHEMICAL RECURRENCE AFTER RADIATION THERAPY
SALVAGE RADICAL PROSTATECTOMY (SRP)
SALVAGE CRYOABLATION OF THE PROSTATE
SALVAGE BRACHYTHERAPY FOR RADIOTHERAPY FAILURE
SALVAGE HIGH-INTENSITY FOCUSED ULTRASOUND (HIFU)
OBSERVATION

GUIDELINES

Also in this page:

GENERAL OVERVIEW

ADT AFTER PRIMARY TREATMENT

CHEMOTHERAPY PLUS HORMONE THERAPY



GENERAL OVERVIEW


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Artibani W, Porcaro AB, De Marco V, Cerruto MA, Siracusano S.
Management of Biochemical Recurrence after Primary Curative Treatment for Prostate Cancer: A Review.
Urol Int. 2017 Nov 21. doi: 10.1159/000481438. [Epub ahead of print]
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Bruce JY, Lang JM, McNeel DG, Liu G.
Current controversies in the management of biochemical failure in prostate cancer.
Clin Adv Hematol Oncol. 2012 Nov;10(11):716-22.
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Paller CJ, Antonarakis ES.
Management of biochemically recurrent prostate cancer after local therapy: evolving standards of care and new directions.
Clin Adv Hematol Oncol. 2013 Jan;11(1):14-23.
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Punnen S, Cooperberg MR, D'Amico AV, Karakiewicz PI, Moul JW, Scher HI, Schlomm T, Freedland SJ.
Management of biochemical recurrence after primary treatment of prostate cancer: a systematic review of the literature.
Eur Urol. 2013 Dec;64(6):905-15. doi: 10.1016/j.eururo.2013.05.025. Epub 2013 May 16.
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Spratt DE, McHugh DJ, Morris MJ, Morgans AK.
Management of Biochemically Recurrent Prostate Cancer: Ensuring the Right Treatment of the Right Patient at the Right Time.
Am Soc Clin Oncol Educ Book. 2018 May 23;(38):355-362. doi: 10.1200/EDBK_200319.
Source | Book | Similar articles



ADT AFTER PRIMARY TREATMENT




OPTIMAL TIMING OF ADT INITIATION

Dale W, Hemmerich J, Bylow K, Mohile S, Mullaney M, Stadler WM.
Patient anxiety about prostate cancer independently predicts early initiation of androgen deprivation therapy for biochemical cancer recurrence in older men: a prospective cohort study.
J Clin Oncol. 2009 Apr 1;27(10):1557-63. doi: 10.1200/JCO.2008.18.5850. Epub 2009 Mar 2.
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Schröder F, Bangma C, Angulo JC, Alcaraz A, Colombel M, McNicholas T, Tammela TL, Nandy I, Castro R.
Dutasteride Treatment Over 2 Years Delays Prostate-specific Antigen Progression in Patients with Biochemical Failure After Radical Therapy for Prostate Cancer: Results from the Randomised, Placebo-controlled Avodart After Radical Therapy for Prostate Cancer Study (ARTS).
Eur Urol. 2013 May;63(5):779-87. doi: 10.1016/j.eururo.2012.11.006. Epub 2012 Nov 12.
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Taneja SS.
Re: dutasteride treatment over 2 years delays prostate-specific antigen progression in patients with biochemical failure after radical therapy for prostate cancer: results from the randomised, placebo-controlled avodart after radical therapy for prostate cancer study (ARTS).
J Urol. 2013 May;189(5):1716. doi: 10.1016/j.juro.2013.01.077. Epub 2013 Jan 30.
Comment relating to: Schröder F et al., Eur Urol. 2013 May;63(5):779-87. doi: 10.1016/j.eururo.2012.11.006. Epub 2012 Nov 12.
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CHEMOTHERAPY PLUS HORMONE THERAPY


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Nakabayashi M, Xie W, Buckle G, Bubley G, Ernstoff MS, Walsh W, Morganstern DE, Kantoff PW, Taplin ME.
Long-term follow-up of a phase II trial of chemotherapy plus hormone therapy for biochemical relapse after definitive local therapy for prostate cancer.
Urology. 2013 Mar;81(3):611-6. doi: 10.1016/j.urology.2012.12.025.
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